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chose cynomolgus monkeys to establish an acute hypobaric hypoxia brain injury model, and the specific steps: altitude simulation was started at 320 m, then suspended at 3000 m, 4500 m, and 6000 m for 50 min each, and finally maintained at 7500 m for an initial 48 h, with a rate of ascent of 3 m/s (Zhang et al., 2021)

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